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An increased liver weight of 110% at one year was not associated with liver tumorigenesis, whereas liver tumorigenicity was seen if the one-year liver weight was 150% of control values (Carmichael et al

R., Smirnov, M

(2) normal blood pressure, defined as systolic blood pressure 0.05

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In fact Lang and coworkers have recently studied eryptosis on young and old human RBC and confirmed that PS exposure was similarly negligible in young and old RBC, but increased upon induction of eryptosis more so in old than young RBC (Ghashghaeinia et al., 2012)

However, transcript levels of pro-inflammatory cytokines were not significantly different between vehicle and roxadustat treated mice in both healthy and stroke-affected brain (Figure S4A) suggesting that systemic roxadustat treatment neither promotes inflammation in the intact CNS nor affects the local pro-inflammatory response during acute ischemic stroke