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Axonal regeneration was induced by adding 1 nM of EpoB (from Sorangium cellulosum

Standard drug development often seeks a single target for a single disease pathway, but these natural agents defy that model

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The slower formation rate of 7 from Ser, relative to that of 1 from Cys, correlates with the higher pKa value of the serinyl hydroxyl group (predicted at 13.4 (ACD/I-Lab, 5.0.0.184, Advanced Chemistry Development, Inc., Toronto, ON, Canada, www.acdlabs.com, (2019)) compared to the cysteinyl thiol group (~8.4 (AAs and acidity values, (accessed 1 May 2019)), suggesting hydroxyl/thiol deprotonation might be (partially) rate limiting 39

These isotopes of iodine emit, primarily, beta radiation (that travel short distances in tissues) and gamma radiation (that can penetrate the entire body)