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As CS inhalation inactivates proteases necessary for protecting the lungs, the development and progression of COPD have been closely related to the oxidation of essential proteins and lipids in the airway epithelium and sputum and the decrease in the levels of antioxidants, such as glutathione and superoxide dismutase (Drost et al., 2005

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The inclusion of Nicotine Polacrilex USP and other nicotine replacement therapies (NRTs) in the guidelines that policymakers have developed is a clear demonstration that harm reduction is a realistic way to lower the burden of diseases that are caused by smoking

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