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To address this problem, Chen et al developed an inhalable alginate quercetin nanogel (QU-Nanogel) based on alginate which is an FDA-approved polysaccharide with good biocompatibility

It is conceivable that active disruption of the myelin sheath and death of myelin-producing oligodendrocytes, infiltrating inflammatory cells, and the release of heme (by increased expression of heme oxygenase-1 (HMOX1), data not shown) could drive disruption of iron homeostasis

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Plates were treated with 500 nM dTAG-V1, 50 nM OTS964 or DMSO (as a solvent control) for the indicated time

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