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Although optimal ARA:DHA ratios are not fully elucidated, the ratio of both LCPUFAs was suggested to impact immune response, cognitive and behavioral outcomes, competition for tissue incorporation and risk for atopic disease (4951)

Given that the regulation of the intracellular cytoskeleton is dependent on the presence of ATP to stimulate the contraction of actin-myosin complexes, a reduction in ATP concentration caused by NSAIDs was found to impair TJs and reduce cellular polarity (Knig et al

Subsequently, it was found that DHA not only induces ferroptosis through lipid peroxide (LPO) accumulation but also promotes immunogenic cell death of lung cancer cells, thereby enhancing anti-tumor effects (65)

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(October 1992)