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Gene bb0318 is critical for the oxidative stress response and infectivity of Borrelia burgdorferi

NADs are a class of gene therapy agents based on DNA, RNA, or synthetic oligonucleotide analogs

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This inference was further supported by a physiologically based pharmacokinetic drug interaction model using the abundant alkaloid mitragynine, a relatively potent CYP3A time-dependent inhibitor in vitro ( K I , ~4 M