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Once TMAO formation/concentration is elevated, it may increase the risks of atherosclerosis for healthy individuals ( TMAO and HF HF is defined as a group of syndromes caused by structural or functional damage that results in impaired ventricular filling or cardiac output, and which involves multi-organ and systemic neurohumoral dysfunction ( Figure 4 )

Finally, for recording fatigue levels, the present study adopted BRAF-NRS Question 1 (64) or the 11-point fatigue numeric rating scale (NRS) (65, 66)

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