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Active PGC-1 travels to the nucleus and upregulates Nuclear Respiratory Factors (NRF-1 and NRF-2), which stimulate the expression of Mitochondrial Transcription Factor A (TFAM)

Methods 11 , 4760 (1984)

Its used to treat B12 deficiency

J Biol Chem 282(8):52965301

ingredient list (inci): sodium palmate, sodium palm kernelate, water, butylene glycol, arbutin, citric acid, sodium sulfite, acetyl tyrosine, saxifraga sarmentosa extract, paeonia suffruticosa root extract, aminopropyl ascorbyl phosphate, scutellaria baicalensis root extract, glutathione, glycerin, sodium lactate, fragrance, disodium lauryl sulfosuccinate, sodium cocoyl isethionate, zea mays, cetearyl alcohol, hydrogenated castor oil, titanium dioxide, cocamide mea, panthenol, allantoin, papain, bht, tetrasodium edta, etidronic acid, ci 19140, ci 15985

Real-world example: Post-game celebratory drinks after a strenuous sports match or a hard gym session are a realistic setting where meaningful fluid loss has already occurred before the first drink is even poured