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Cochlear explants were pretreated with 2 mM bucillamine for 1 h before the addition of 30 M cisplatin

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Some evidence suggests the Trx pathway can respond to cellular damage by activating the cytoprotective Nrf2 stress-response pathway, which, in turn, induces expression of the genes encoding components of both the Trx and the GSH systems (Arner, 2009